Psychosis like symptoms are induced by
excessive use of cannabis and these are
very much alike pure psychosis as schizophrenia.
Several studies have demonstrated that the primary active constituent of cannabis, delta-9-tetrahydrocannabinol (∆9-THC), induces transient psychosis-like effects in healthy subjects similar to those observed in schizophrenia. However, the mechanisms underlying these effects are not clear. A new study reported that THC increases random neural activity also consider as neural noise, in the brains of healthy human subjects. The findings suggest that increased neural noise may play a role in the psychosis-like effects of cannabis. At doses roughly equivalent to half or a single joint, produced psychosis-like effects and increased neural noise in humans. The dose-dependent and strong positive relationship between these two findings suggest that the psychosis-like effects of cannabis may be related to neural noise which interrupts the brain's normal information processing.
The investigators studied the effects of cannabis on electrical brain activity in 24 human subjects who participated in a three-day study during which they received two doses of intravenous THC or placebo in a double-blind, randomized, cross-over, and counterbalanced design. Dr. John Krystal stated that, this interesting study suggests a commonality between the effects on the brain of the major active ingredient in marijuana and symptoms of schizophrenia. The impairment of cortical function could cause some of the cognitive effects of marijuana. This finding aid in understanding the processes of underlying psychosis, it highlighted an important concern in the debate surrounding medical and legalized access to marijuana.
Source: Medical News Today